Maomao, an apothecary's daughter, has been plucked from her peaceful life and sold to the lowest echelons of the imperial court. Now merely a maid, Maomao settles into her new mundane life and hides her extensive knowledge of medicine in order to avoid any unwanted attention. Not long after Maomao's arrival, the emperor's infant children inexplicably begin to experience grave symptoms—almost as if a curse has been cast. The curious Maomao easily solves the mystery and, to remain out of the limelight, attempts to leave an anonymous tip. Unfortunately, the dashing and perceptive eunuch Jinshi sees through it and manages to single her out. In recognition of her talent, Maomao is promoted to lady-in-waiting for the emperor's favorite concubine, Gyokuyou. As Maomao continues to remedy the numerous ailments afflicting the imperial court, her pharmaceutical expertise quickly proves indispensable.

This is the story of Puniru the slime and Kotarou, a middle school student, until they cease being friends... Kotarou Kawaii is a second-year middle school boy. When he was in elementary school, a slime he created came to life, and for the past seven years, he has been spending time with the slime named Puniru as his "friend." However, there is one problem for Kotarou... Over the seven years, both have grown significantly, and Puniru has transformed into an incredibly beautiful girl! Besides her beautiful appearance, Puniru freely transforms into various cute forms as a slime, causing Kotarou to be both excited and bewildered by her carefree behavior every time. Will Puniru and Kotarou be able to continue spending time together as "friends" despite these challenging days ahead? (Source: Official website)